Vincent C. Bond, BS, MS, Ph.D.
Professor Emeritus
Microbiology, Biochemistry & Immunology
E-mail: vbond@msm.edu
Education
POSTGRADUATE:California Institute of Technology
Fellowship: Postdoctoral
GRADUATE:
Pennsylvania State University
Degree: Doctor of Philosophy in Genetics
Pennsylvania State University
Degree: Master of Science in Genetics
UNDERGRADUATE:
Pennsylvania State University
Degree: Bachelor of Science in Biology
Research Interests
Our research integrates virology, cancer biology, and microbial pathogenesis within the field of natural products鈥搃nspired therapeutics. We have identified the HIV Nef secretion modification region (SMR), engineered into a bioactive peptide that functions as a Short Linear Motif (SLiM) targeting host chaperones and extracellular vesicle pathways. This SMR-derived peptide reveals conserved mechanisms linking viral modulation, tumorigenesis, and bacterial biofilm formation, including demonstrated disruption of E. coli and MRSA biofilms. These findings suggest the SMR exploits evolutionarily conserved cellular processes, positioning it as a novel natural product鈥搇ike scaffold with broad therapeutic potential.
Publications
Shelton MN, Huang MB, Ali SA, Powell MD, and Bond VC. 2012. SMR-derived peptide disrupts HIV-1 Nef鈥檚 interaction with mortalin and blocks
virus and Nef exosome release. J Virol. Jan, 86(1): 406-19. PMC3255900.
Kim DK, Lee J, Kim SR, et al. 2013. EVpedia: A Community Web Portal for Extracellular
Vesicles Research. Bioinformatics. doi:10.1093/bioinformatics/btu741. PMC4375401.
Konadu KA, Chu J, Huang MB, Amancha PK, Armstrong W, Powell MD, Villinger F, Bond VC. 2014. Cytokines Associate with Exosomes in the Plasma of HIV-1+ Individuals. Journal
of Infectious Diseases. doi: 10.1093/infdis/jiu676. PMC4447830
Konadu KA, Anderson JS, Huang MB, Ali SA, Powell MD, Villinger F, Bond VC. 2015. Hallmarks of HIV-1 pathogenesis are modulated by Nef鈥檚 Secretion Modification Region. J AIDS Clin Res Jul; 6(7). pii: 476. Epub 2015 Jun 30. PMC4625552.
Konadu KA, Huang MB, Roth W, Armstrong W, Powell M, Villinger F, Bond VC. 2016. Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals. J Vis Exp. 2016 Jan 5;(107). doi: 10.3791/53495. PMC4780996
Huang MB, Gonzalez RR, Lillard J, Bond VC. Secretion Modification Region-Derived Peptide Blocks Exosome Release and Mediates Cell Cycle Arrest in Breast Cancer Cells. OncoTarget. 2017, Jan 5. doi: 10.18632/oncotarget.14513. PMC5355266
Click to view additional publications.
Patents
Bond, VC, Lillard JW, Huang, MB. USP10,040,831 B2. 08/07/18. Compositions and methods for treating diseases by inhibiting exosome release.
Bond VC, Powell M, Huang MB, Ali S., Shelton MN. USP 8,669,226. 03/11/14. Antimicrobial compositions and methods of use thereof.
Bond VC, Powell M, Huang MB, Ali S. USP 10,053,496. 08/21/18. Compositions and methods for exosome targeted expression.
Honors and Awards
2015: Outstanding Mentor Award, Ph.D.
2014: Outstanding Mentors Award, MSCR Student Association
2012: Outstanding Mentors Award, PhD Student Association
2008: Faculty Appreciation Award, PhD Student Association